Neurgain’s technology is making a new approach to treating the SOD1 variant of ALS possible.
Delivery of the SOD silencing vector to the entire spinal cord is achieved by using Neurgain’s Subpial injection technology. Studies in adult pigs have demonstrated widespread expression in the entire length of the cord.
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs.
Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M.
Mol Ther Methods Clin Dev. Article 2016; 3:16046. doi: 10.1038/mtm.2016.46. eCollection 2016. PubMed PMID: 27462649; PubMed Central PMCID: PMC4943453,