Who We Are
Neurgain Technologies, Inc., was founded in 2013 by Martin Marsala, Professor of Anesthesiology, UC San Diego School of Medicine, and Michael Krupp, CEO—a proven leader with a track record in large pharma companies and leading several startups including Xfibra, Inc., to develop the technologies arising from Dr. Marsala’s. Dr. Marsala’s work has focused on the treatment of spinal cord trauma-includuced neuropathic pain and has produced numerous scientific publications and several patents.
The Company has licensed these technologies from UC San Diego. Our business strategy involves:
- Out-licensing of animal-proven spinal cord delivery technology (i.e subpial delivery); and
- Product development to a regulatory filing of a gene therapy for neuropathic pain and chronic spasticity. We plan to use out-licensing as means to engage and co-develop with established company partners, who could in turn help realize the developmental milestones.
Publications
Dec 23, 2019, Nature Medicine
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
Authors: Mariana Bravo-Hernandez, Takahiro Tadokoro, .., Martin Marsala
Presentations
Spinal Subpial Delivery of AAV9 Produces a Potent, Long-Lasting Block of Neuraxial Degeneration and Disease Manifestation in Adult Mice by Silencing an ALS-Causing Mutant Gene
Authors: Mariana Bravo-Hernandez1, Takahiro Tadokoro1, Michael Navarro1, Oleksandr Platoshyn1, Yoshiomi Kobayashi1, Silvia Marsala1, Atsushi Miyanohara1, Shawn P. Driscoll1, Thomas D. Glenn1, Melissa McAlonis-Downes1, Sandrine Da Cruz1, Samuel L. Pfaff1, Brian K. Kaspar2, Don W. Cleveland1, Martin Marsala1
1Anesthesiology, Ludwig Institute, Salk Institute, UCSD, La Jolla, CA, 2Avexis Inc, Chicago, IL
ASGCT 22nd Annual Meeting, Abstract April 29, 2019
Reversal of Chronic Neuropathic Pain by Functional Neurotransmitter Rewiring of Spinal Nociceptive Neurons after Spinal Segment-Targeted Subpial Dual Gene (GAD65 and VGAT) Delivery
Authors: Takahiro Tadokoro, Mariana Bravo-Hernandez, Oleksandr Platoshyn, Atsushi Miyanohara, Silvia Marsala, Martin Marsala
Anesthesiology, University of California, San Diego, La Jolla, CA
ASGCT 22nd Annual Meeting, Abstract May 2, 2019
A potent anti-nociceptive effect after spinal subpial AAV9-medited GAD65 and VGAT gene delivery: a systematic study in neuropathic mice and adult pig
Authors: *Takahiro Tadokoro, Atsushi Miyanohara, Oleksander Platoshyn, Mariana Bravo Hernandez, Silvia Marsala, Martin Marsala.
Anesthesiology, University of California, San Diego, La Jolla, CA
SOCIETY for NEUROSCIENCE, Abstract, November 2018
A potent treatment effect after spinal subpial adeno-associated virus (AAV9) shRNA-SOD1 delivery in adults ALS SOD1G37Rmice.
Authors: *M. Bravo Hernandez1, T. Tadokoro1, O. Platoshyn1, S. Marsala1, S. Da Cruzz, B. K. Kaspar4,5, D. W. Cleveland2,3, M. Marsala1;
1Anesthesiol., Univ. of California San Diego, La Jolla, CA; 2Ludwig Inst. for Cancer Res., 3Dept. of Cell. and Mol. Med., Univ. of California San Diego, San Diego, CA; 4Ohio State Univ., Res. Inst. at Nationwide Childrens Hosp., Columbus, OH; 5Avexis, Bannockburn, IL
SOCIETY for NEUROSCIENCE, Abstract, November 2018