Advisors

Dr. Krupp is currently the CEO of two startup companies, Neurgain Technologies and Xfibra, Inc., that are based on UC San Diego technologies. In addition, He also is a Business and Technology Adviser the Institute for the Global Entrepreneur at the UCSD Jacobs School of Engineering focused on the Life Sciences area. Previously Dr. Krupp was Sr. V.P. of Business Development and Chief Business Officer of Chugai Pharma USA, LLC (CPUSA) in San Diego. Dr. Krupp was responsible for identifying and acquiring products and technology to complement and expand CPUSA’s project pipeline. He was responsible for the market research and strategic marketing efforts for Chugai drug candidates outside of Japan including the anti-IL-6 receptor antibody, Actemira, a novel agent for the treatment of rheumatoid arthritis.  He was also responsible for general business operations. Prior to Chugai, Dr. Krupp served as Director, Licensing and Development, at Pfizer, Inc. He started his industry career in Pfizer Central Research in the areas of Diabetes drug discovery and General Pharmacology. Dr. Krupp received his B.S. in Chemistry from Hobart College and his Ph.D. in Biochemistry from the University of Rochester, School of Medicine. He completed his Postdoctoral Research at The Johns Hopkins University School of Medicine.

Professor of Anesthesiology at University of California San Diego

Dr. Marsala, is the co-founder and chief scientific officer of Neurgain Technologies, Inc.

He has over 25 years of research experience in the field of Neuroscience. A significant element of Dr. Marsala’s spinal injury investigations is focused on the development of gene-therapy based treatments to modulate spinal excitatory system and to suppress spinal trauma-induced spasticity and chronic pain. Dr. Marsala is the originator of subpial delivery technique in small and large preclinical animal models. He is also the originator of dual gene therapy approach for the treatment of neuropathic pain. He is a current member of the clinical team which conducts a Phase I clinical trial to test the safety of human spinal stem cells after spinal grafting in chronic spinal trauma patients at UCSD.

Dr. Marsala earned his doctoral degree from Safarik’s University of Medical School, Kosice, Slovakia.

Dr. Tadokoro is an experienced research scientist and expert in small and large animal spinal microsurgeries/technique to deliver therapeutic substances into spinal subpial space.

Prior to joining the Neurgain Technologies, Dr. Tadokoro was a Postdoctoral Fellow at the Department of Anesthesiology, University of California San Diego. His work focused on the characterization of pathophysiology and treatment of spinal neurodegenerative disorders including chronic peripheral nerve and spinal cord injury-induced neuropathic pain.  Prior to his position at UCSD, Dr. Tadokoro worked as an anesthesiologist at the University of Ryukyus, Okinawa.

Dr. Tadokoro received his medical degree from the University of Tsukuba, Cluster of Medical Sciences.

Dr. Silvia Marsala is the operations manager, and the coordinator and administrator for preclinical non-GLP and GLP studies. Prior to joining Neurgain’s leadership team, Dr. S. Marsala held the position of Project Scientist at the Department of Anesthesiology, University of California San Diego and her research focused on cell-replacement based therapies in small and large preclinical animal models and assessing the therapeutic potential of neural precursor cells in enhancing functional recovery following spinal cord injury.

Dr. Marsala earned her degree from the University of Veterinary Medicine and Biotechnology in Kosice, Slovakia.

Director of Vector Development Lab at the Department of Anesthesiology, UCSD

Dr. Miyanohara has a broad background in molecular biology, with extensive experience in the development of lentiviral and adenoviral vectors for in vitro and in vivo delivery.

Dr. Miyanohara has supervised the Vector Core Laboratory of the University of California San Diego, Program in Human Gene Therapy since 1995. His primary research focus has been on the development of safe and efficient gene transfer vectors for gene therapy applications, cell reprogramming, and transgenesis.

Dr. Miyanohara received his B.S. degree in Biochemistry from Kyushu University, Fukuoka, Japan and his Ph.D. degree in Medical Sciences from the Osaka University, Suita in Japan.

A senior organizational leader in the development and commercialization of human therapeutics, held a leadership positions at several biotechnology and pharmaceutical companies. Formerly he served as a Senior Vice President, Regulatory Affairs and Quality at Bonti, Inc., Head of Global Regulatory Affairs CMC at Allergan, a Senior Director of Technical Operations at Micromet in Germany, and CMC Specialist, a Global Regulatory Leader at Amgen, California.

He received his degree in Biological Sciences, the University of Southern California, and the Regulatory Science, John Hopkins University.

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